Rurality, productivity and skills in the East Midlands: final report

This report sets out the findings of research into the relationship between rurality, skills and productivity in the East Midlands. The report has been prepared by the Enterprise Research and Development Unit (ERDU) at the University of Lincoln on behalf of the East Midlands Development Agency (emda)

Stationary and non-stationary fluid flow of a Bose-Einstein condensate through a penetrable barrier

We experimentally study the fluid flow induced by a broad, penetrable barrier moving through an elongated dilute gaseous Bose-Einstein condensate. The barrier is created by a laser beam swept through the condensate, and the resulting dipole potential can be either attractive or repulsive. We examine both cases and find regimes of stable and unstable fluid flow: At slow speeds of the barrier, the fluid flow is stationary due to the superfluidity of the condensate. At intermediate speeds, we observe a non-stationary regime in which the condensate gets filled with dark solitons. At faster speeds, soliton formation completely ceases and a remarkable absence of excitation in the condensate is seen again.Comment: 4 pages, 4 figure

Rurality, productivity and skills in the East Midlands: exec summary

Exec Summary to the Rurality Productivity and Skill

Mechanism, dynamics, and biological existence of multistability in a large class of bursting neurons

Multistability, the coexistence of multiple attractors in a dynamical system, is explored in bursting nerve cells. A modeling study is performed to show that a large class of bursting systems, as defined by a shared topology when represented as dynamical systems, is inherently suited to support multistability. We derive the bifurcation structure and parametric trends leading to multistability in these systems. Evidence for the existence of multirhythmic behavior in neurons of the aquatic mollusc Aplysia californica that is consistent with our proposed mechanism is presented. Although these experimental results are preliminary, they indicate that single neurons may be capable of dynamically storing information for longer time scales than typically attributed to nonsynaptic mechanisms.Comment: 24 pages, 8 figure

A contribution to the selection of emission-line galaxies using narrow-band filters in the optical airglow windows

Emission line galaxies are an invaluable tool for our understanding of the evolution of galaxies in the Universe. Imaging of deep fields with narrow-band filters allows not only the selection of these objects, but also to infer the line flux and the equivalent width of the emission line with some assumptions. The narrow-band filter technique provides homogeneous samples of galaxies in small comoving volumes in the sky. We present an analysis of the selection of emission-line galaxies using narrow-band filters. Different methods of observation are considered: broad-band -- narrow-band filters and two broad-band and one narrow-band filters. We study also the effect of several lines entering simultaneously inside the filters (this is the case of Halpha). In each case the equations to obtain the equivalent width and line flux from the photometry are obtained. Candidates to emission-line objects are selected by their color excess in a magnitude-color diagram. For different narrow-band filters, we compute the mean colors of stars and galaxies, showing that, apart from galaxies, some types of stars could be selected with certain filter sets. We show how to compute the standard deviation of the colors of the objects even in the usual case when there are not enough objects to determine the standard deviation from the data. We present also helpful equations to compute the narrow-band and the broad-band exposure times in order to obtain minimum dispersion in the ratio of fluxes of both bands with minimum total exposure time.Comment: Accepted for publication in PASP 48 pages, 10 figures Corrected typos, fixed references. Updated reference to T

A Role for the Vacuolating Cytotoxin, VacA, in Colonization and Helicobacter pylori-Induced Metaplasia in the Stomach

Carriage of Helicobacter pylori strains producing more active (s1/i1) forms of VacA is strongly associated with gas-tric adenocarcinoma. To our knowledge, we are the first to determine effects of different polymorphic forms of VacA on inflammation and metaplasia in the mouse stomach. Bacteria producing the less active s2/i2 form of VacA colonized mice more efficiently than mutants null for VacA or producing more active forms of it, providing the first evidence of a positive role for the minimally active s2/i2 toxin. Strains producing more active toxin forms induced more severe and extensive metaplasia and in flammation in the mouse stomach than strains producing weakly active (s2/i2) toxin. We also examined the association in humans, controlling for cag PAI status. In human gastric biopsy specimens, the vacA i1 allele was strongly associated with precancerous intestinal metaplasia, with almost complete absence of intestinal metaplasia in subjects infected with i2-type strains, even in a vacA s1, cagA+ background

Power-Based Droop Control in DC Microgrids Enabling Seamless Disconnection From Upstream Grids

This paper proposes a local power-based droop controller for distributed energy resource converters in dc microgrids that are connected to upstream grids by grid-interface converters. During normal operation, the grid-interface converter imposes the microgrid bus voltage, and the proposed controller allows power flow regulation at distributed energy resource converters\u2019 output. On the other hand, during abnormal operation of the grid-interface converter (e.g., due to faults in the upstream grid), the proposed controller allows bus voltage regulation by droop control. Notably, the controller can autonomously convert from power flow control to droop control, without any need of bus voltage variation detection schemes or communication with other microgrid components, which enables seamless transitions between these two modes of operation. Considering distributed energy resource converters employing the power-based droop control, the operation modes of a single converter and of the whole microgrid are defined and investigated herein. The controller design is also introduced. Furthermore, the power sharing performance of this control approach is analyzed and compared with that of classical droop control. The experimental results from a laboratory-scale dc microgrid prototype are reported to show the final performances of the proposed power-based droop control

Heart failure following cancer treatment: characteristics, survival and mortality of a linked health data analysis

Background: Cardiotoxicity resulting in heart failure is a devastating complication of cancer therapy. A patient may survive cancer only to develop heart failure (HF), which has a higher mortality rate than some cancers. Aim: This study aimed to describe the characteristics and outcomes of HF in patients with blood or breast cancer after chemotherapy treatment. Methods: Queensland Cancer Registry, Death Registry and Hospital Administration records were linked (1996–2009). Patients were categorised as those with an index HF admission (that occurred after cancer diagnosis) and those without an index HF admission (non-HF). Results: A total of 15 987 patients was included, and 1062 (6.6%) had an index HF admission. Median age of HF patients was 67 years (interquartile range 58–75) versus 54 years (interquartile range 44–64) for non-HF patients. More men than women developed HF (48.6% vs 29.5%), and a greater proportion in the HF group had haematological cancer (83.1%) compared with breast cancer (16.9%). After covariate adjustment, HF patients had increased mortality risk compared with non-HF patients (hazard ratios 1.67 (95% confidence interval, 1.54–1.81)), and 47% of the index HF admission occurred within 1 year from cancer diagnosis and 70% within 3 years. Conclusion: Cancer treatment may place patients at a greater risk of developing HF. The onset of HF occurred soon after chemotherapy, and those who developed HF had a greater mortality risk